The three dimensional SDH model showed good stereo-chemical and structural properties. We employed computational methodologies to design new SDH inhibitors using homology modeling pharmacophore modeling and structure based virtual screening. Hence targeting Alternaria solani SDH enzyme could be efficient tool to design novel fungicides against A. The enzyme Succinate dehydrogenase (SDH) is a potential drug target because of its role in tricarboxylic acid cycle. 6UoN Chair of Oman Medicinal Plants and Marine Products, University of Nizwa, Nizwa, OmanĪlternaria blight is an important foliage disease caused by Alternaria solani.5Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, Pakistan.4Plant Breeding, Wageningen University and Research, Wageningen, Netherlands. 3Department of Biochemistry, Kinnaird College for Women, Lahore, Pakistan.2Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.1Institute of Agricultural Sciences, University of the Punjab, Lahore, Pakistan.Vleeshouwers 4 Ajmal Khan 5,6 * Ahmed Al-Harrasi 6 Shahbaz Ahmad 1
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